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Abstract Among the many different pieces of physics that go into simulations of the circumgalactic medium (CGM), the metagalactic ultraviolet background (UVB) plays a significant role in determining the ionization state of different metal species. However, the UVB is uncertain, with multiple models having been developed by various research groups over the past several decades. In this work, we examine how different UVB models influence the ionic column densities of CGM absorbers. We use these UVB models to infer ion number densities in the Figuring Out Gas and Galaxies In Enzo (FOGGIE) galaxy simulations atz= 2.5 and use the Synthetic Absorption Line Surveyor Application package to identify absorbers. Absorbers are then matched across UVB models based on their line-of-sight position so that their column densities can be compared. From our analysis, we find that changing the UVB model produces significant changes in ionization, specifically at lower gas densities and higher temperatures where photoionization dominates over collisional ionization. We also find that the scatter of column density differences between models tends to increase with increasing ionization energy, with the exception of Hi, which has the highest scatter of all species we examined. 

The all-terrain motility of lymphocytes in tissues and tissue-like gels is best described as amoeboid motility. For amoeboid motility, lymphocytes do not require specific biochemical or structural modifications to the surrounding extracellular matrix. Instead, they rely on changing shape and steric interactions with the microenvironment. However, the exact mechanism of amoeboid motility remains elusive. Here, we report that septins participate in amoeboid motility of T cells, enabling the formation of F-actin and α-actinin–rich cortical rings at the sites of cell cortex–indenting collisions with the extracellular matrix. Cortical rings compartmentalize cells into chains of spherical segments that are spatially conformed to the available lumens, forming transient “hourglass”-shaped steric locks onto the surrounding collagen fibers. The steric lock facilitates pressure-driven peristaltic propulsion of cytosolic content by individually contracting cell segments. Our results suggest that septins provide microenvironment-guided partitioning of actomyosin contractility and steric pivots required for amoeboid motility of T cells in tissue-like microenvironments.